Madman

Description
Danger indicators are disabled, including bosses.

Effects
Danger indicators (primarily used in boss fights) show a danger's trajectory before it is performed (usually projectiles).

This makes the game more difficult if the player experiences an enemy/boss fight for the first time.

Unlock Condition
Win a run.

This does not require a specific difficulty, meaning that the easiest way to unlock this relic is by putting the DHMIS difficulty.

Trivia

 * Currently, this is the least rewarding relic in the game, both in teeth awarded and score multiplier.
 * This item's internal name is Big_Duke.