Ostilloporosion

Description
Fall damage can be lethal; Environmental damage (including fall damage) is doubled.

Effects
When the player can now suffer fall damage which is higher than his current health, instead of rounding up to be "Current Health - 1". Environmental damage is doubled, meaning that increasing defense or getting items which reduce environmental damage (such as Masterless Toolkit) does take the increase in damage into account. Note: Fall damage is also doubled, however it cannot be mitigated as fall damage is considered as true damage.

This makes the game harder by making carelessness more punishing.

Unlock Condition
Complete a run without taking any fall damage.

This is done easiest with the catwalk upgrade.

Trivia

 * This item's name is a word play on a medical disorder called Osteoporosis, characterized by low bone density.