Minimalism

Description
At the start of a run, three item flags are rolled; You cannot equip any items which are flagged with said flags.

Effects
Every item in the game has a multitude of flags which describe it's effects and purpose. As an example, Phase Wing has the following flags: MOVEMENT_SPEED, MOBILITY, UTILITY, GRAVITY, DASHING.

Now let's say the 3 flags you roll on a run are: DAMAGE, BULLET_COUNT, MOBILITY.

Any item that contains any of these flags will be unable to be equipped, meaning that Phase Wing cannot be equipped in this instance, however Grass could.

Unlock Condition
Reach The Volcano without equipping any items on Equilibrum difficulty or higher.

The Volcano is usually the 4th stage, meaning that you need to start the game, and defeat at least of 3 stages before unlocking this relic.

Note that any item equipped will automatically fail the unlocking condition, including items gained through Teeth Upgrades.

Trivia

 * This relic's quote is a reference to Fight Club.