Daimonation

Description
Start the game with a demonic item which you cannot remove; Only it's negative effects are applied.

Effects
Selects a random item from the list of all unlocked demonic items, and gives it to the player at the start of the game; However, it's positive effects are never applied. Every demonic item's negative effect is so punishing that without a demonic item's positive effect to make up for, most other relics don't compare.

This makes the game harder by punishing the player for existing.

Unlock Condition
Successfully equip 5 demonic items.

The key here is luck (or lack thereof).

Trivia

 * This relic's name is a reference to a song called Daimonas by Until We Die.
 * This relic's quote is a shot at demon summoning where the practicionner hopes that a succubus is summoned.